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Infectious Disease: Pandemics
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Total 142803 results found since Jan 2013.
HIV-1 Variable Loop 2 and its Importance in HIV-1 Infection and Vaccine Development.
Abstract
A vaccine that can prevent the transmission of HIV-1 at the site of exposure to the host is one of the best hopes to control the HIV-1 pandemic. The trimeric envelope spike consisting of heterodimers, gp120 and gp41, is essential for virus entry and thus has been a key target for HIV-1 vaccine development. However, it has been extremely difficult to identify the types of antibodies required to block the transmission of various HIV-1 strains and the immunogens that can elicit such antibodies due to the high genetic diversity of the HIV-1 envelope. The modest efficacy of the gp120 HIV-1 vaccine used in the ...
Source: Current HIV Research - November 4, 2013 Category: Infectious Diseases Authors: Rao M, Peachman KK, Kim J, Gao G, Alving CR, Michael NL, Rao VB Tags: Curr HIV Res Source Type: research
The interplay between HIV and COVID-19: summary of the data and responses to date
Conclusion
COVID-19 is threatening gains against the HIV epidemic, including the U.S. Ending the HIV Epidemic goals. The ongoing collision of these two global pandemics will continue to need both study and interventions to mitigate the effects of COVID-19 on HIV efforts worldwide.
Source: Current Opinion in HIV and AIDS - December 15, 2020 Category: Infectious Diseases Tags: COVID/HIV: Edited by R. Brad Jones Source Type: research
Recent Advances on the Use of Structural Biology for the Design of Novel Envelope Immunogens of HIV-1.
Abstract
Many efforts have been made in the worldwide quest for a prophylactic HIV vaccine to end the AIDS pandemic, but none has yet succeeded. The lessons learned have repeatedly informed us that the traditional or conventional approaches directly using the pathogens or subunits will not be sufficient for an effective HIV/AIDS vaccine. Recent advances in structure-based technology have shown some promise in the quest for a better immunogen in HIV vaccine development. According to the basic binding structural relationship of an antigen and an antibody, structure-based antigen design could bring some hope for the ...
Source: Current HIV Research - September 10, 2013 Category: Infectious Diseases Authors: Shi-Hua X Tags: Curr HIV Res Source Type: research
Factors associated with HIV counseling and testing and correlations with sexual behavior of teachers in primary and secondary schools in Addis Ababa, Ethiopia
Conclusion: No significant differences were observed between primary and secondary school teachers regarding factors associated with HCT and its correlation with sexual behavior. Gender, age, marital status, knowledge of HCT, and perceived risk were found to be factors associated with HCT uptake. Correlations between being faithful to a partner, inconsistent use of condoms, and HCT uptake of teachers were also observed. Thus, strengthening the current practice of HCT services in the education sector with due emphasis on the observed factors could play a pivotal role in bringing about positive changes in the sexual behavior...
Source: HIV/AIDS - Research and Palliative Care - June 30, 2015 Category: Infectious Diseases Tags: HIV/AIDS - Research and Palliative Care Source Type: research
Adaptation of advanced clinical virology assays from HIV-1 to SARS-CoV-2
Purpose of review
In response to the HIV–AIDS pandemic, great strides have been made in developing molecular methods that accurately quantify nucleic acid products of HIV-1 at different stages of viral replication and to assess HIV-1 sequence diversity and its effect on susceptibility to small molecule inhibitors and neutralizing antibodies. Here, we review how knowledge gained from these approaches, including viral RNA quantification and sequence analyses, have been rapidly applied to study SARS-CoV-2 and the COVID-19 pandemic.
Recent findings
Recent studies have shown detection of SARS-CoV-2 RNA in blood of ...
Source: Current Opinion in HIV and AIDS - December 15, 2020 Category: Infectious Diseases Tags: COVID/HIV: Edited by R. Brad Jones Source Type: research
The course of COVID-19 in four patients with HIV during the pandemic.
CONCLUSION: In this study, the effect of the immunological status of the patients on the course of COVID-19 and the developing vascular complications were evaluated in 4 patients with HIV.
PMID: 33261541 [PubMed - as supplied by publisher]
Source: Current HIV Research - November 30, 2020 Category: Infectious Diseases Authors: Turken M, Altan H, Atalay S, Kose S Tags: Curr HIV Res Source Type: research
COVID-19 antibody development fueled by HIV-1 broadly neutralizing antibody research
Purpose of review
The coronavirus disease 2019 (COVID-19) pandemic has caught the world unprepared, with no prevention or treatment strategies in place. In addition to the efforts to develop an effective vaccine, alternative approaches are essential to control this pandemic, which will most likely require multiple readily available solutions. Among them, monoclonal anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies have been isolated by multiple laboratories in record time facilitated by techniques that were first pioneered for HIV-1 antibody discovery. Here, we summarize how lessons learned f...
Source: Current Opinion in HIV and AIDS - December 15, 2020 Category: Infectious Diseases Tags: COVID/HIV: Edited by R. Brad Jones Source Type: research
The first 6 months of HIV-SARS-CoV-2 coinfection: outcomes for 6947 individuals
Purpose of review
The aim of this review is to summarize the clinical outcomes of people living with HIV (PWH) coinfected with SARS-CoV-2 during the first six months of the COVID-19 pandemic.
Recent findings
Several reports from single centers have described increased, decreased, or no difference in outcomes of COVID-19 in PWH. These studies have come from a range of locations, each with different underlying HIV prevalence and access to various antiretroviral therapy (ART) regimens. Differences in healthcare quality, access and policies may also affect reported outcomes in PWH across different locations, making ...
Source: Current Opinion in HIV and AIDS - December 15, 2020 Category: Infectious Diseases Tags: COVID/HIV: Edited by R. Brad Jones Source Type: research
Impact of COVID-19 on HIV Testing and Care Provision Impact of COVID-19 on HIV Testing and Care Provision
The significant impacts of the COVID-19 pandemic on access to HIV testing and treatment could have long-term consequences.HIV Medicine
Source: Medscape Hiv-Aids Headlines - February 24, 2022 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news
HIV Care May Have Slipped During the Pandemic HIV Care May Have Slipped During the Pandemic
An analysis by Komodo Health suggests there was less HIV screening, fewer new HIV diagnoses, and fewer new PrEP prescriptions during the pandemic ' s first year compared with the year before.Medscape Medical News
Source: Medscape Hiv-Aids Headlines - June 30, 2022 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news
Mental Health Conditions in People With HIV During COVID-19 Mental Health Conditions in People With HIV During COVID-19
A new review examines the mental health effects of the COVID-19 pandemic on people living with HIV.HIV Medicine
Source: Medscape Hiv-Aids Headlines - October 13, 2022 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news
COVID-19 First Wave Impact Survey for HIV Clinicians COVID-19 First Wave Impact Survey for HIV Clinicians
A survey of HIV clinicians provides insight into the impact of the first wave of the COVID-19 pandemic on clinics and staff.HIV Medicine
Source: Medscape Hiv-Aids Headlines - November 28, 2022 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news
Impact of COVID-19 on HIV Adolescent Programming Impact of COVID-19 on HIV Adolescent Programming
The COVID-19 pandemic disrupted access to HIV services for adolescents, which could risk achieved gains in HIV epidemic control.JAIDS: Journal of Acquired Immune Deficiency Syndromes
Source: Medscape Hiv-Aids Headlines - July 20, 2023 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news
Almost 16 Million on HIV Treatment as AIDS Pandemic Tide TurnsAlmost 16 Million on HIV Treatment as AIDS Pandemic Tide Turns
Some 15.8 million people worldwide are now on HIV treatment and a fast-track strategy to end the AIDS pandemic is starting to show results, the United Nations AIDS program said on Tuesday. Reuters Health Information
Source: Medscape Hiv-Aids Headlines - November 25, 2015 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news
Online-to-offline models in HIV service delivery
Purpose of review: Half the world's population has access to Internet and technologies, and utilization is near-ubiquitous among providers and key populations. Despite being so well connected; identifying, reaching and linking vulnerable populations to HIV clinical services remains a global challenge. This review highlights the emerging online-to-offline (O2O) models, their potential in scaling up services, and evaluating impact, and implications for future research.
Recent findings: Globally, four major types of O2O models have been implemented, primarily in the West and Asia, especially among MSM and transgender women. ...
Source: Current Opinion in HIV and AIDS - August 3, 2017 Category: Infectious Diseases Tags: HIV AND NEW TECHNOLOGIES: Edited by Nittaya Phanuphak, Lisa B. Hightow-Weidman, and David A. Wohl Source Type: research
